The son of Microsoft Corp. Chief Executive Satya Nadella has died, a spokesperson for the company said Tuesday. 

“Very sadly Satya’s son Zain Nadella has passed away. The Nadellas are taking time to grieve privately as a family,” the spokesperson said. 

Zain Nadella, who was in his mid-20s, was born with cerebral palsy, which his father has...

The son of Microsoft Corp. Chief Executive Satya Nadella has died, a spokesperson for the company said Tuesday. 

“Very sadly Satya’s son Zain Nadella has passed away. The Nadellas are taking time to grieve privately as a family,” the spokesperson said. 

Zain Nadella, who was in his mid-20s, was born with cerebral palsy, which his father has credited for softening his outlook on work and life. 

Cerebral palsy is caused by abnormal development of the brain and affects a person’s ability to move and maintain balance, according to the Centers for Disease Control and Prevention. It can result in intellectual disability, seizures, and problems with vision, hearing or speech.  

Satya Nadella has praised Microsoft’s efforts in designing products meant for people with disabilities, such as videogame hardware.

The Nadellas have made philanthropic contributions to healthcare organizations, including efforts to transform children’s health in Washington state, where Microsoft is based and where Mr. Nadella has said he lives. 

“Zain has had to struggle against tremendous adversity due to his medical condition,” Seattle Children’s Hospital, which has dedicated an endowed chair position in Zain’s name, wrote last year. “His journey has shaped the Nadella family’s story to one of resilience, empathy, and determination to realize the promise of a brighter future for children with neurological conditions,” the hospital said.

Write to Omar Abdel-Baqui at omar.abdel-baqui@wsj.com